Conveners
Session I
- Keng-hui Lin
The separation of yolk from the embryonic cytoplasm characterizes the initial phase of embryonic development in oviparous animals, including fish, frogs and flies. While yolk-cytoplasm separation is known for allocation of energy resources and partitioning of maternally deposited patterning elements critical for cell fate specification, it remains unknown whether such separation changes the...
The interplay between inside-out and outside-in activation of integrin receptor orchestrates cell motility and tissue regeneration. While such mechanisms of RGD-binding integrin, including integrin beta1 and beta3, are well documented, mechano-sensitive regulations of integrin beta6 remain largely unknown. Using the viscous RGD-membrane as the model system, we find that integrin beta6 and...
Elastic tissues such as arteries and tendons have dense extracellular matrices with wavy structures that allow high strain. The resident cells follow the wavy structures that change with load, disease, and aging. Few studies, however, study the impacts of this wavy morphology on cell behavior and mechanotransduction. Using microfabrication techniques, we precisely control single cell shape and...
