Physical Models of Living Matters - The 3rd Symposium of Physical Biology and Biological Physics

Session

Session I

30 Aug 2024, 13:30

205 Meeting Room (The Aspire Resort, Taoyuan)

Conveners

Session I

• Keng-hui Lin

4. The resilience and diversification of mechanical stress management during morphogenesis

Prof. Yu-chiun Wang (RIKEN)

30/08/2024, 13:30

The separation of yolk from the embryonic cytoplasm characterizes the initial phase of embryonic development in oviparous animals, including fish, frogs and flies. While yolk-cytoplasm separation is known for allocation of energy resources and partitioning of maternally deposited patterning elements critical for cell fate specification, it remains unknown whether such separation changes the...

5. Mechanosensitive regulation of integrin beta6 mediated adhesion

Cheng-han Yu (The University of Hong Kong)

30/08/2024, 14:00

The interplay between inside-out and outside-in activation of integrin receptor orchestrates cell motility and tissue regeneration. While such mechanisms of RGD-binding integrin, including integrin beta1 and beta3, are well documented, mechano-sensitive regulations of integrin beta6 remain largely unknown. Using the viscous RGD-membrane as the model system, we find that integrin beta6 and...

6. Phase separation promotes receptor clustering and downstream signaling

Prof. Lindsay Case (MIT)

30/08/2024, 14:20

In many signaling pathways, receptors are spatially organized at the plasma membrane into signaling clusters with a specific composition. Phase separation driven by protein interactions can promote clustering of many types of receptors, including the LAT receptor, Nephrin receptor, and integrin receptor. We use biochemical reconstitutions and cellular experiments to study compositionally...

35. Wavy Morphology Regulates Cell Structure, Migration, and Phenotype

Prof. Grace Pen-hsiu Chao (NTU)

30/08/2024, 14:50

Elastic tissues such as arteries and tendons have dense extracellular matrices with wavy structures that allow high strain. The resident cells follow the wavy structures that change with load, disease, and aging. Few studies, however, study the impacts of this wavy morphology on cell behavior and mechanotransduction. Using microfabrication techniques, we precisely control single cell shape and...