Conveners
Session IV
- Chi-Shuo Chen
The organization and dynamics of chromatin is essential for the regulation of gene expression. Transcription factors (TFs) regulate gene expression by binding to specific consensus motifs within enhancers or promoter-proximal regions. The mechanism by which TFs bind to their cognate chromatin targets within a complex nuclear environment to assemble transcriptional machinery at specific genomic...
The activation of integrins and the subsequent formation of focal complexes is a critical function in cellular sensing of ECM substrates and cell migration. Integrin adhesion complexes (IACs) allow for cell adhesion, transduce force, and signal through several pathways. While much work has been done to uncover the components and regulators involved in adhesion formation and dynamics, we have...
The study of chromatin nanostructures in living cells is complex due to their constant motion. In this talk, I will introduce a novel correlation spectroscopy approach using interferometric scattering (iSCAT) microscopy, which allows for the spatial mapping of chromatin configurations and dynamics in live, unlabeled cell nuclei. This innovative label-free method detects linear scattering...
