Conveners
Session VI
- Tai-De Li
In Nature, many dynamic processes take place in purely aqueous environments within relatively narrow range of environmental conditions, such as temperature. How such sophisticated processes across hierarchical lengthscales in the natural biological world remains fascinating to materials scientists. One of the key phenomena that drives the formation of a diverse range of structures is aqueous...
Biological membranes undergo dynamic remodeling that is essential for cellular homeostasis. BAR protein SNX9 is known to play a key role in actin-driven membrane remodeling, for example at saddle-shaped or tubular membrane necks connecting vesicular buds to the plasma membrane during endocytosis, and in the more complex membrane remodeling of membrane ruffling during macropinocytosis. SNX9 has...
This study delves into the molecular dynamics that underpin critical biological processes in neurodegeneration. We use molecular dynamics simulations to investigate the interactions of Abeta42 monomers with fibrillar surfaces, a pivotal factor in Alzheimer's disease progression. Employing coarse-grained simulations, we focus on the diffusion behaviors of freely diffusing Abeta42 monomers...
Membrane curvature in the range of tens to hundreds of nanometers is involved in many essential cellular processes. Membrane curvatures in living cells are often below optical resolution and are highly dynamic, making it a technical challenge to explore curvature-initiated signaling events. We use nanofabrication to engineer vertical nanostructures to precisely manipulate the location, degree,...
