Speaker
Description
We have worked on the influence of matrix stiffness on cellular physiology in epithelial cells and fibroblasts as well, which plays a very important role in pathophysiology of organ and tissue fibrosis. The current research theme of my research has been to unveil the mechanobiological mechanism of converting wound repair into regeneration. We have discovered that breaking symmetry of cell contractility by lowering the matrix stiffness leads to augmented wound-induced hair follicle neogenesis in mice (Nature Commun 2021) and renal tubule morphogenesis in vitro (PNAS 2024 ). Thus, lowered matrix stiffness promote tissue regeneration and differentiation. In this talk, I will present our data how matrix stiffness controls the fate of stem cell lineage specification.
