Conveners
Session V
- Chia-Ching (Josh) Wu
"Replication-dependent histone (Repli-Histo) labeling specifically visualizes physical properties of euchromatin/heterochromatin in living human cells.
Katsuhiko Minami1, 2, Satoru Ide1, 2, Sachiko Tamura1, and Kazuhiro Maeshima1, 2
1 Genome Dynamics Laboratory, National Institute of Genetics
2 Graduate Institute for Advanced Studies, SOKENDAI
Abstract
Recent advanced imaging studies...
Microtubules are hollow cylindrical cytoskeletal polymers of laterally associated protofilaments that contain head-to-tail aligned ɑ/β-tubulin heterodimers. While the exposed exterior is within reach for proteins, the mechanism regulating the accessibility of the confined micrometer-long microtubule lumen for the long-observed luminal particles remains unknown. Here, we employed structural...
Differentiated cardiomyocytes (CMs) must undergo diverse morphological and functional changes during postnatal development. However, the initiation and coordination of these processes remain unclear. We reveal an integrated, time-ordered transcriptional network that begins with expression of genes for cell-cell connections and leads to a sequence of structural, cell cycle, functional, and...
Physical spacing of chromatin is critical in regulating bio-chemical and transcriptional abilities of genes, and proper functionality of the genomic content depends on the nonrandom organization of chromatin. Meanwhile, in a living cell, other subnuclear molecules, such as enzymes like polymerase and topoisomerase, act to facilitate cellular functions. Mechanical perturbation due to actions of...
