Physical Models of Living Matters - The 3rd Symposium of Physical Biology and Biological Physics

Session

Session V

31 Aug 2024, 14:00

205 Meeting Room (The Aspire Resort, Taoyuan)

Conveners

Session V

• Chia-Ching (Josh) Wu

13. Replication-dependent histone (Repli-Histo) labeling specifically visualizes the physical properties of euchromatin/heterochromatin in living human cells

Prof. Kazuhiro Maeshima (National Institute of Genetics)

31/08/2024, 14:00

"Replication-dependent histone (Repli-Histo) labeling specifically visualizes physical properties of euchromatin/heterochromatin in living human cells.
Katsuhiko Minami1, 2, Satoru Ide1, 2, Sachiko Tamura1, and Kazuhiro Maeshima1, 2
1 Genome Dynamics Laboratory, National Institute of Genetics
2 Graduate Institute for Advanced Studies, SOKENDAI

Abstract
Recent advanced imaging studies...

17. Tubulin isotypes harness the mechano-sensitive lattice breathing for microtubule luminal accessibility

Prof. Jeff Shih-Chieh Ti (The University of Hong Kong)

31/08/2024, 14:30

Microtubules are hollow cylindrical cytoskeletal polymers of laterally associated protofilaments that contain head-to-tail aligned ɑ/β-tubulin heterodimers. While the exposed exterior is within reach for proteins, the mechanism regulating the accessibility of the confined micrometer-long microtubule lumen for the long-observed luminal particles remains unknown. Here, we employed structural...

15. Epigenetic Mechanisms in Cardiomyocyte Maturation

Prof. Cheng-fu Kao (Academia Sinica)

31/08/2024, 14:50

Differentiated cardiomyocytes (CMs) must undergo diverse morphological and functional changes during postnatal development. However, the initiation and coordination of these processes remain unclear. We reveal an integrated, time-ordered transcriptional network that begins with expression of genes for cell-cell connections and leads to a sequence of structural, cell cycle, functional, and...

21. Numerical studies on the influence of mechanical perturbations due to actions of subnuclear molecules on chromatin organization and dynamics

Prof. Tetsuya Hiraiwa (Academia Sinica)

31/08/2024, 15:20

Physical spacing of chromatin is critical in regulating bio-chemical and transcriptional abilities of genes, and proper functionality of the genomic content depends on the nonrandom organization of chromatin. Meanwhile, in a living cell, other subnuclear molecules, such as enzymes like polymerase and topoisomerase, act to facilitate cellular functions. Mechanical perturbation due to actions of...