Speaker
Description
Kinesin motors are essential for intracellular organelle transport. While extensive studies have focused on understanding their collective motion, the reasons for the wide distribution of cargo speeds in cells remain poorly understood. In this study, we examine the relationship between motor numbers, cellular crowding, and cargo velocity during cargo transport in vitro. Our findings indicate that increased motor numbers enhance cargo speed in crowded environments, depending on the size of the crowding agents, helping to explain the observed broad distribution of cargo velocities in vivo. Moreover, kinesin tension plays an essential role in collective motion, supported by stochastic kinesin simulations. This interdisciplinary approach offers insight into complex biological processes and encourages future investigations into motor cooperation and environmental factors in intracellular transport.
