The 4th Physical Biology and Biological Physics Symposium - The Biological Physics Across Scales From Single Molecules to Organisms

Session

Kindlin2 controls integrin mechanosensitivity and adhesion stabilization

Session II - 1 Chair: Shi-wei Chu)

16 Jan 2026, 10:50

Conveners

Kindlin2 controls integrin mechanosensitivity and adhesion stabilization

• Cheng-han Yu (The University of Hong Kong)

1. Kindlin2 controls integrin mechanosensitivity and adhesion stabilization

Cheng-han Yu (The University of Hong Kong)

Invited Speaker

Integrin activation dynamically orchestrates adhesion formation and cell motility within the heterogeneous extracellular space. However, mechanosensitive regulation of integrin β6 remains poorly understood. Using a traction‑free RGD membrane, integrin β6 colocalizes and nucleates micrometer‑scale clusters of viscous RGD ligands by 15 minutes and subsequently dissipates by 60 minutes. Swapping...