The 4th Physical Biology and Biological Physics Symposium - The Biological Physics Across Scales From Single Molecules to Organisms

Session

Diffusion with a Twist: Geometry-Controlled Aβ Dynamics on the Path to Fibril Growth

Session VI - 1 Chair: Chi-shuo Chen

17 Jan 2026, 10:30

Conveners

Diffusion with a Twist: Geometry-Controlled Aβ Dynamics on the Path to Fibril Growth

• Min-Yeh Tsai (National Chung Cheng University)

45. Diffusion with a Twist: Geometry-Controlled Aβ Dynamics on the Path to Fibril Growth

Prof. Min-Yeh Tsai (National Chung Cheng University)

Invited Speaker

Amyloid-β (Aβ) aggregation provides a prototypical example of geometry-regulated self-assembly in biological systems. While amyloid growth is often described in terms of chemical kinetics or tip-growth models, how single-molecule diffusion on fibril surfaces is shaped by physical constraints remains incompletely understood. Here, we use coarse-grained molecular dynamics simulations to...