Workshop on Random Walks in Biological Physics with Focus on DNA and chromosome structure

Lecture 2: DNA Twisting and Supercoiling (John F. Marko)

Not scheduled

1h 30m

1F Auditorium (Institute of Physics, Academia Sinica)

Lecture 2

Speaker

Prof. John F. Marko (Northwestern University)

Description

DNA Twisting and Supercoiling. Torsional stiffness; biological origin and role of supercoiling; Gauss invariant; Lk = Wr + Tw; TWLC model; plectonemic supercoiling; torsional-stress-driven strand separation; magnetic tweezers experiments; DNA force-torque "phase diagram"; topoisomerases; GapR.