Workshop on Random Walks in Biological Physics with Focus on DNA and chromosome structure

Session

Lecture 2

16 Apr 2026, 13:30

1F Auditorium (Institute of Physics, Academia Sinica)

Description

Torsional stiffness; biological origin and role of supercoiling; Gauss invariant; Lk = Wr + Tw; TWLC model; plectonemic supercoiling; torsional-stress-driven strand separation; magnetic tweezers experiments; DNA force-torque "phase diagram"; topoisomerases; GapR.

4. Lecture 2: DNA Twisting and Supercoiling (John F. Marko)

Prof. John F. Marko (Northwestern University)

DNA Twisting and Supercoiling. Torsional stiffness; biological origin and role of supercoiling; Gauss invariant; Lk = Wr + Tw; TWLC model; plectonemic supercoiling; torsional-stress-driven strand separation; magnetic tweezers experiments; DNA force-torque "phase diagram"; topoisomerases; GapR.