Workshop on Random Walks in Biological Physics with Focus on DNA and chromosome structure

Session

Lecture 4

17 Apr 2026, 10:00

1F Auditorium (Institute of Physics, Academia Sinica)

Conveners

Lecture 4: DNA Topology and Its Regulation In Vivo (Prof. John F. Marko)

• Keng-Hui Lin (Institute of Physics, Academia Sinica)

Description

Polymer entanglement; entanglement and knotting lengths; chromosome dynamics during cell cycle; lengthwise compaction model; active loop extrusion model; SMC complexes (condensin, cohesin, SMC5/6 bacterial SMCs); experiments supporting
loop extrusion model.

5. Lecture 4: DNA Topology and Its Regulation In Vivo (John F. Marko)

Prof. John F. Marko (Northwestern University)

DNA Topology and its Regulation in vivo. Polymer entanglement; entanglement and knotting lengths; chromosome dynamics during cell cycle; lengthwise compaction model; active loop extrusion model; SMC complexes (condensin, cohesin, SMC5/6 bacterial SMCs); experiments supporting
loop extrusion model.